Hypocretin release in normal and narcoleptic dogs after food and sleep deprivation, eating, and movement.

Hypocretin/orexin release in normal and narcoleptic dogs: Effects of food deprivation, eating, sleep deprivation and movement

Narcolepsy without cataplexy: 2 subtypes based on CSF hypocretin-1/orexin-A findings.

STUDY OBJECTIVES Cerebrospinal fluid (CSF) hypocretin-1 levels and their relationship with the clinical characteristics of narcolepsy without cataplexy have not been well elucidated. Our aim was to examine whether clinical characteristics vary with CSF hypocretin-1 levels among narcoleptic patients without cataplexy. DESIGN Clinical features, variables on the multiple sleep latency test, and ...

Developmental changes in CSF hypocretin-1 (orexin-A) levels in normal and genetically narcoleptic Doberman pinschers.

Loss of hypocretin cells or mutation of hypocretin receptors causes narcolepsy. In canine genetic narcolepsy, produced by a mutation of the Hcrtr2 gene, symptoms develop postnatally with symptom onset at 4 weeks of age and maximal symptom severity by 10-32 weeks of age. Canine narcolepsy can readily be quantified. The large size of the dog cerebrospinal fluid (CSF) cerebellomedullary cistern al...

Narcolepsy A Neurodegenerative Disease of the Hypocretin System?

that narcoleptic dogs have mutations in one of the hypoIn the 2⁄2 years since hypocretin (also called orexin) was cretin receptors, the hypocretin receptor 2 (orexin 2 refirst described (de Lecea et al., 1998; Sakurai et al., ceptor) (Lin et al., 1999). Although different mutations 1998), more than 120 papers on the peptide have already were found in each of two narcoleptic breeds of dogs, been...

Role of the hypocretin (orexin) receptor 2 (Hcrt-r2) in the regulation of hypocretin level and cataplexy.

Hypocretin receptor-2 (Hcrt-r2)-mutated dogs exhibit all the major symptoms of human narcolepsy and respond to drugs that increase or decrease cataplexy as do narcoleptic humans; yet, unlike narcoleptic humans, the narcoleptic dogs have normal hypocretin levels. We find that drugs that reduce or increase cataplexy in the narcoleptic dogs, greatly increase and decrease, respectively, hypocretin ...